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you have a much higher incidence of unburnt hydrocarbons (fuel) passing straight through- hence the need to time the injectors with the engines firing sequence.
This is an emissions-control problem and a slight fuel-economy problem, but not a performance problem. Most multi-port injection systems are not timed to the firing sequence. The Ford multiport "sequential" V8 system was, but the GM multiport system was not. The GM smallblock V8 made just as much horsepower.