Weak point? A series Datsun engines? Surely a contradiction in terms.
These are an amazingly robust design & can take a lot of hard use without complaint. If your base is a GX engine, then you already have a good head & any problems will depend on the intended use, & the level of outright abuse.
The GX manifold/header is still factory recomended for use in rally engines with dual Hitachi [SU type] carbs, but a tube header was recomended for all out racing, so I presume that the GX manifold/header flows pretty good up to about 6.000 to 7.000 rpm.
Several people have reported flywheels coming loose after a missed shift at racing speeds where RPM rose to frightening levels, so if you think that there is a chance that your engine will see anything like a five digit number on the tach, then doweling the flywheel to the crank is a good idea.
There is also a school of thought that says that a custom made harmonic balancer will help a great deal in this area as well, & one Datsun racer near here seems to be having quite some success with one on his engine, but again, this is prety much justified as a race-only item
Balancing is always a good thing in any hot engine.
Roller rockers are nice, & I have them for my street engine, but I am just stroking my ego with these as they are simply not justified either operationally or in price for road use. I justified their purchase to myself on some flimsy engineering pretext, &, well, because I could.
If your engine will see sustained RPM up near the red line, then these will be a good thing.
Other than that, I don't think that there are any real weak points in the design itself & the usual mantra of carefull component selection, & carefull assembly will see a strong & reliable engine in your chassis.
More [Datsun] power to you.