At cruise you are primarily using the idle and progression circuits. The main jets and air correctors only really come into play once the throttles are 70-80% open.

Idle and progression are what give you driveability so you need to sort out your low rev issues.

What idle jets and holders do you have installed?
How many progression holes are there?

By all means work on the full throttle jetting but do it after you have fixed part throttle response!