Dodgeman...people have been fitting oversized engines into cars since the creation of the earth...but the question is will the chassis dymanics allow the car to turn a corner at speed....thats real engineering. The Blitzen Benz was made in 1909 by Mercedes...for the land speed record of 141.37mph in 1911 . It had a 4 cylinder 21.5 litre engine in it. I redlined at 1500 rpm and had 200 HP...but the car couldnt turn a corner.
I think you should have the smallest engine to start with ie A-series and work on the chassis and handling dynamics first. Once the chassis outclasses the power and the drivers up to it...then think extra HP/cubes