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The more compression, the less advance the engine can handle. But a high-compression engine can still use some advance, and even a forced-induction engine needs some advance to make the most power at varying RPMs. The key is LIMITING the advance to a safe level.
Consequences of too much spark advance: cracked pistons, broken ring lands
What about locking the distributor? Yes, if you lock the advance mechanism, yes, it can help prevent detonation, but also it won't make the best power. Locked distributor will only work great at high-RPM, high-boost condition -- which is where racers spend most of their time, so it works well for racing. For a street engine, you will have a more flexible, more powerful engine at all RPMs by NOT locking the distributor, but by limiting the advance.
CONSTANT-LOAD RACING METHOD
- Lock the distributor advance. Set full timing to an appropriate level, say 30 degrees for a high-compression engine or for maximum advance at 16 psi boost: 23 degrees.
LOW-DOLLAR STREET POWER METHOD
- In the distributor, weld the advance slots partially to limit mechanical advance (see Limiting Mechanical Advance)
- Keep the stock vacuum advance (it will have no effect under heavy throttle or boost)
- Connect vacuum advance up directly to manifold. This will help idle and starting out under low throttle, but the vacuum advance will have no effect under heavier throttle
- Set initial timing to lower than normal, say 3 degrees or 0 degrees (instead of the normal 5-7)
- Downside: On a forced-induction engine, the advance won't be right for varying boost levels. You'll have to set the advance for full boost scenario, giving up HP and fuel economy for lower throttle conditions such as highway cruising
BEST METHOD: fully programmable ignition
- use a crank trigger with a fully programmable ignition system. MegaSquirt and other ECUs can provide initial timing, limited full timing, timing under boost and even retard under boost and compensate for high temperatures.
- use a standalone advance controller like the Block Box or an MSD Programmable, which allows for limited mechanical advance along with variable retard under boost, off-boost, and partial-boost conditions. With such a controller, the distributor is locked, and the box takes over the exact timing curve.