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I guess the Skyline could be had with AWD. Similar to the S13-S15, right?
R32 Skyline suspension is similar to s14 and I believe R33 is like S14 but the difficulty in using a skyline system is it's designed for the RB 6 cyclinder and one driveshaft actually passes through the oil pan I think. Changing to a 4 cylinder would present some engineering issues... not impossible but difficult. Using the 6 cylinder engine in a B310 would be difficult to say the least, particularly as you'd have no choice as to the engine position as it would be dictated by the front axle location.
It would probably be easier to build a system around GTiR running gear but having had a GTiR for a little while i wouldn't want to...fast but they don't handle well. Too much understeer and to unpredictable through twisty roads. It would be a great deal easier to engineer GTiR stuff into a B11 than a B310.
As for your gas tank. I had an M10 Nissan Prairie (Stanza wagon in the US) which I put a CA18ET into and retained the stock tank and converted to EFI. I used a low pressure electric pump to move fuel from the tank to a small surg tank I made which was mounted under the floor. A high pressure EFI pump was fed from this and the fuel from the fuel rail returned to it. Think of the system as two circuits. the low pressure side circulates fuel from the main tank to the surge tank and back again and the high pressure, from the surge tank to the engine and back to to surge tank. With flat underfloor tanks you are likely to get fuel stavation when cornering so a surge tank is a good idea. I made mane from a piece of flat plate, the top of a 4" disposible welding gas cylinder and some carburettor pipe unions. I probably still have pictures of it somewhere.
Honestly, a CA18DET into a B310 is a pretty easy swap so you should have no real problems if you go that route.